What is RSV?
- RSV is a respiratory virus, occurring during cold seasons around the world.
- Globally RSV is responsible for more than 30 million infections every year.
- In infants under 2, RSV is the most common cause of bronchiolitis and pneumonia. The mortality rate for hospitalised infants is between 2-3% in most developed countries, including the US.
- High-risk populations include: premature infants, children with congenital heart or lung disease, those with weakened immune systems, people with immunodeficiencies, the elderly, and adults with CHF or COPD.
- There are currently no licensed antivirals for widespread use in treating RSV infection.
ReViral is focused on the discovery and development of the next generation of antivirals to treat RSV infection.
- A potent, novel, oral small molecule RSV (A&B) fusion (F) inhibitor.
- Phase 1 clinical trial showed good safety profile and exposure that exceeds levels predicted for antiviral activity.
- Highly potent activity measured by viral load and symptoms in Phase 2a adult challenge model.
- Entering an international multicentre Phase 2 paediatric trial.
RSV Replication Inhibitors:
Programmes that inhibit RSV replication by mechanisms other than fusion are in lead optimisation.
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